Chemical Nanosensors Research Group
Introduction of the Research Group
The Chemical nanosensor research group received among others the financial support of the Hungarian Academy of Science through their Lendület program for research groups of excellence in Hungary and of the Melinda&Bill Gates Foundation. The main activity of the research group focus focuses on the development of chemical and biosensors primarily for medical diagnostics. The research extends from the development of novel synthetic receptors (aptamers, ionophores, molecularly imprinted polymers, etc. ) to the implementation of new chemically modified nanomaterials and full integration of the chemical and biosensors in microfluidic platforms. The main research topics of the group includes the development of virus sensors, wearable sensors, epitope imprinted polymers, nanopore sensors, high throughput chip technology for biomarker and receptor screening.
Achievements
- Solid state ion selective electrodes (for wearable sensor application, e.g. measuring the ion composition of sweat during sport activities; the electrodes can be applied also for measuring the concentration of ions (e.g., Ca, Na, K, Cl, pH) in body fluids (blood, urine, breath condensates)- Selective solid state ion channels based on chemically modified nanopores (e.g., Ag and Cu measurements)
- Virus counters able to detect individual virus particles in liquids and as such to determine their concentration and concentration in calibration-free manner
- Molecularly imprinted polymers for selective protein recognition (a new class of robust synthetic affinity ligands, i.e. plastic antibodies that are able to replace antibodies in diagnostic applications and bioaassays)
- Nanopore-based sensing platform for calibration-free quantitation and sizing of nanoparticles in liquids
Publications
(1) Bognár, Z.; Supala, E.; Yarman, A.; Zhang, X.; Bier, F. F.; Scheller, F. W.; Gyurcsányi, R. E. Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARS-CoV-2 RBD protein, Chemical Science 2022, 13, 1263-1269. https://doi.org/10.1039/D1SC04502D(2) Szakács, Z.; Mészáros, T.; de Jonge, M. I.; Gyurcsányi, R. E. Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis, Nanoscale 2018, 10, 13942-13948. https://doi.org/10.1039/C8NR01310A
(3) Papp, S.; Jágerszki, G.; Gyurcsányi, R. E. Ion-Selective Electrodes Based on Hydrophilic Ionophore-Modified Nanopores, Angewandte Chemie-International Edition 2018, 57, 4752-4755. https://doi.org/10.1002/anie.201800954
(4) Terejánszky, P.; Makra, I.; Fürjes, P.; Gyurcsányi, R. E. Calibration-Less Sizing and Quantitation of Polymeric Nanoparticles and Viruses with Quartz Nanopipets, Analytical Chemistry 2014, 86, 4688-4697. https://doi.org/10.1021/ac500184z
(5) Menaker, A.; Syritski, V.; Reut, J.; Opik, A.; Horváth, V.; Gyurcsányi, R. E. Electrosynthesized Surface-Imprinted Conducting Polymer Microrods for Selective Protein Recognition, Advanced Materials 2009, 21, 2271-+. https://doi.org/10.1002/adma.200803597
Patents
Microfabricated sensor array comprising first electrode, working electrode such as microdisk or interdigitated array, and optical aperture adapted to receive light from sample liquid patent WO2004001404-A1; US2004040868-A1; AU2003259038-A1; EP1514097-A1; JP2005530179-W WO2004001404-A1 31 Dec 2003 G01N-027/327 200408. Denuzzio JD, Lindner E, Gyurcsányi RE; BECTON DICKINSON & CO (BECT-C) DENUZZIO J D (DENU-Individual) LINDNER E (LIND-Individual) GYURCSANYI R E (GYUR-Individual) BECTON DICKINSON & CO (BECT-C), assignee.Awards
• Editor, Sensors and Actuators B: Chemical, Elsevier B.V. (2012-2017) • Co-Editor-in Chief, Sensors and Actuators B: Chemical, Elsevier B.V. (2017-) • Master teacher Gold Medal, Council of National Scientific Students' Associations, 2017 • Albert Szent-Györgyi Prize, Ministry of Human Capacities, 206 • Momentum Research Group grantee of the Hungarian Academy of Sciences, 2013 • Memorial Plaquette for outstanding advisory activity in Scientific Student Competitions, BME, 2012 • Bill&Melinda Gates Foundation Grantee, 2011 • Outstanding Faculty Award, Faculty of Chemical Technology and Biotechnology, BME, 2011 • Pro Progressio prize (for mentoring), Pro Progressio Foundation, 2008 • Ernő Pungor Prize, Hungarian Academy of Sciences, 2008 • Talentum Prize, in Natural Sciences, awarded by the Central-European Talent Search Foundation, 2007 • Sigma Prize, Sigma-Aldrich Rt., 2006 • Bolyai Plaquette, Hungarian Academy of Sciences, 2005 • Bolyai János Research Fellowship, Hungarian Academy of Sciences, 2005-2008 • Teacher of the Year at BME awarded by international students, 2003 • Bolyai János Research Fellowship, Hungarian Academy of Sciences, 2001-2004 • Young Scientist Award of the Hungarian Academy of Sciences, 2000 • First prize at the “7th International Scientific Instrument Technology Workshop”, Hsinchu, Taiwan, 1997Journals
Nanoscale, Angewandte Chemie, Nano Letters, Advanced Functional Materials, Advanced Materials, Chemical Science, Chemical Communications, Analytical Chemistry, Biosensors&Bioelectronics, Electroanalysis, Electrochimica Acta, Analytica Chimica ActaInfrastructure
Surface Plasmon Resonance Imaging Fluorescence Imaging Nanoparticle counter Hypersectral Optical Imaging Research Grade Plate reader Dynamic Light Scattering Atomic Force Microscopy Electrochemical Workstations (galvanostat/Potentiostat/Impedance analysers) 3D Printer FTIR-ATR Patch clamp amplifier Glove box (argon)Projects
Marie Curie Research Training Network MRTN-CT-2006-033873 Nanomaterials for Application in Sensors, Catalysis and Emerging TechnologiesChemically modified synthetic nanopores for label free detection of biomolecular interactions, OTKA NF69262
Chip Architectures by Joint Associated Labs for European diagnostics (CAJAL4EU) ENIAC 120215
Invention of Mobile Poliovirus Diagnosis Platform, Bill & Melinda Gates Foundation
Chemical Nanosensors based on Synthetic Receptors, MTA Lendület II LP2013-63/2013
Artificial receptors based on surface imprinted electrosynthesized polymer nanostructures for protein sensing, OTKA NN 117637
Industry relations
77 ElektronikaVolkswagen AG
Conferences
International Conference on Electrochemical Sensors, Visegrád, 2017, Róbert Gyurcsányi, organizerInternational Conference on Chemical Sensors, Visegrád, 2019, Róbert Gyurcsányi, organizer
International Conference on Chemical Sensors, Visegrád, 2022, Róbert Gyurcsányi, organizer
Coast 2022 – 1st Conference of Applied Surface Technology, May 16-17, 2022, Wiener Neustadt, Róbert Gyurcsányi, invited speaker
71st Annual Meeting of the International Society of Electrochemistry, Belgrade, Serbia, 30 August - 4 September 2020, Róbert Gyurcsányi, Invited keynote speaker
9th International Workshop on Surface Modification for Chemical and Biochemical Sensing, 8 - 12 November 2019, Poland, Róbert Gyurcsányi, invited speaker
XXV International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society, May 26-30, 2019, Limerick, Ireland, Róbert Gyurcsányi, invited keynote speaker
17th International Meeting on Chemical Sensors July 15-19, 2018, Vienna, Austria, Róbert Gyurcsányi, invited plenary speaker
Pittcon 2018, 27 Feb - 1 Mar 2018, Orlando, FL, USA, 2018, Róbert Gyurcsányi, invited speaker