Dr. György Keglevich

Publications

1. Jablonkai, E.; Keglevich, G. P-ligand-free, microwave-assisted variation of the Hirao reaction under solvent-free conditions; the P–C coupling reaction of >P(O)H species and bromoarenes. Tetrahedron Lett. 2013, 54, 4185–4188. doi: 10.1016/j.tetlet.2013.05.111.
2. Keglevich, G.; Jablonkai, E.; Balázs, L.B. A “green” variation of the Hirao reaction: the P–C coupling of diethyl phosphite, alkyl phenyl-H-phosphinates and secondary phosphine oxides with bromoarenes using a P-ligand-free Pd(OAc)2 catalyst under microwave and solvent-free conditions. RSC Adv., 2014, 4, 22808–22816. doi: 10.1039/c4ra03292f.
3. Keglevich, G.; Henyecz, R.; Mucsi, Z.; Kiss, N.Z. The palladium acetate-catalyzed microwave-assisted Hirao reaction without an added phosphorus ligand as a “green” protocol: A quantum chemical study on the mechanism. Adv. Synth. Catal. 2017, 359, 4322–4331. doi: 10.1002/adsc.201700895.
4. Henyecz, R.; Oroszy, R.; Keglevich, G. Microwave-assisted Hirao reaction of heteroaryl bromides and >P(O)H reagents using Pd(OAc)2 as the catalyst precursor in the absence of added P-ligands. Curr. Org. Chem. 2019, 23, 1151–1157. doi: 10.2174/1385272823666190621114915.
5. Henyecz, R.; Huszár, B.; Grenitzer, V.; Keglevich, G. A study on the reactivity of monosubstituted benzenes in the MW-assisted Pd(OAc)2-catalyzed Hirao reaction with Ph2P(O)H and (EtO)2P(O)H reagents, Curr. Org. Chem. 2020, 24, 1048–1054. doi: 10.2174/1385272824999200403170827.
6. Jablonkai, E.; Balázs, L.B.; Keglevich, G. A P-ligand-free nickel-catalyzed variation of the Hirao reaction under microwave conditions. Curr. Org. Chem. 2015, 19, 197–202. doi: 10.2174/1385272819666150114235413.
7. Henyecz, R.; Mucsi, Z.; Keglevich, G. Palladium-catalyzed microwave-assisted Hirao reaction utilizing the excess of the diarylphosphine oxide reagent as the P-ligand; a study on the activity and formation of the “PdP2” catalyst. Pure Appl. Chem. 2019, 91, 121–134. doi: 10.1515/pac-2018-1004.
8. Henyecz, R.; Mucsi, Z.; Keglevich, G. A surprising mechanism lacking the Ni(0) state during the Ni(II)-catalyzed P–C cross-coupling reaction performed in the absence of a reducing agent – An experimental and a theoretical study. Pure Appl. Chem. 2020, 92, 493–503. doi: 10.1515/pac-2019-1004.
9. Keglevich, G.; Henyecz, R.; Mucsi, Z. Experimental and theoretical study on the “2,2-bipiridyl-Ni-catalyzed” Hirao reaction of >P(O)H reagents and halobenzenes: a Ni(0) → Ni(II) or a Ni(II) → Ni(IV) mechanism? J. Org. Chem. 2020, doi: 10.1021/acs.joc.0c00804.
10. Vincze, D.; Ábrányi-Balogh, P.; Bagi, P.; Keglevich, G. A mechanistic study on the tautomerism of H-phosphonates, H-phosphinates and secondary phosphine oxides. Molecules 2019, 24, 3859. doi: 10.3390/molecules24213859.
11. Jablonkai, E.; Keglevich, G. P–C bond formation by coupling reaction utilizing >P(O)H species as the reagents. Curr. Org. Synth. 2014, 11, 429–453.
12. Jablonkai, E.; Keglevich, G. A survey of the palladium–catalyzed Hirao reaction with emphasis on green chemical aspects. Curr. Green Chem. 2015, 2, 379–391.
13. Keglevich, G.; Kiss, N. Z.; Mucsi, Z.; Körtvélyesi. T. Insights into a surprising reaction: The microwave-assisted direct esterification of phosphinic acids. Org. Biomol. Chem. 2012, 10, 2011–2018.
14. Keglevich, G.; Mucsi Z. Interpretation of the rate enhancing effect of microwaves. In Microwave Chemistry; Cravotto, G., Carnaroglio, D., Eds.; De Gruyter: Berlin, 2017; pp 53–64.
15. Keglevich, G.; Kiss, N. Z.; Mucsi, Z. Milestones in microwave-assisted organophosphorus chemistry. Pure Appl. Chem. 2016, 88, 931–939.

Awards

Rektori dicséret (1988), MKE Nívódíj (1989), Zemplén Géza Ifjúsági Díj (1991), az év oktatója (1993), Pro Scientia emlékérem (1997), Széchenyi professzori ösztöndíj (1997–2000), Erdey László Díj (BME VBK tudományos díj, 1999), TDK Emlékplakett (a BME legmagasabb TDK díja, 2001), Tudással Magyarországért Díj (2002), Mestertanári kitüntetés (2003), Ipolyi Arnold Díj (OTKA, 2003), MTA Díj (2004), Bruckner Győző Díj (2005), Than Károly emlékérem (MKE, 2012), Csűrös Zoltán Díj (BME VBK technológiai díj 2013), a Magyar Köztársaság Lovagkeresztje (2021), József Nádor Díj (2022)

Projects

- Continuous leadership in the last 30 years in the 4- year projects founded by the National Scientific Research Fund (earlier OTKA) in the subject of organophosphorus chemistry and green chemistry
- 4 TéT collaborations with French, Polish, Russian and Slovenian partners.
- sub-leadership in the "Research University" projects on green chemistry
participation in the FIEK and FIKP projects.

Conferences

The 22. International Conference on Organophosphorus chemistry was organized by me in Budapest Hungary in 2018 July.

Patents

S Garadnay, A. Grün, J. Neu, G. Keglevich: HUP 1100071, WO 2012107787, 2011.
The rational synthesis of dronic acid derivatives.

Other activities

Editorial Board memberships: 1993– Magyar Kémikusok Lapja, 2002– Heteroatom Chemistry, 2003– Magyar Kémiai Folyóirat, 2006– Phosphorus, Sulfur, Silicon, 2014- Periodica Polytechnica, 2014- Current Microwave Chemistry, 2017- Molecules (gree section), 2021- Green processing and Synthesis.
Editor: 2017- Current Organic Chemistry: Editor-in-Chief, (earlier 2010-től European Editor); 2012– Current Green Chemistry: Editor-in Chief; Symmetry (Chemical Section: Symmetry and Asymmetry): 2021- Editor-in Chief; 2011- Letters in Organic Chemistry: Associate, then Regional Editor; 2011- Letters of Drug Design and Discovery: Associate Editor; 2014- Current Organic Synthesis: Associate Editor.